Stem cell researchers characterize RPE maturation processes required in order to maximise potential of transplanted cells.
Collaborative research, led by investigators at the Institute of Molecular Physiology, Johannes-Gutenberg University, Mainz, Germany, and the US National Eye Institute, NIH, Bethesda, Maryland, have shown that the success of transplantation of stem cell derived RPE to the retina is critically dependent on correctly functioning RPE cilia. The study is published in Cell Reports 22, […]Read full story
CRISPR / Cas 9 gene editing technology shows promising anti-VEGF affects in lab models of angiogenesis.
Researchers, led by investigators at the Schepens Eye Research Institute of Massachusetts Eye and Ear, and the Department of Ophthalmology, Harvard Medical School, Boston, have shown that recently developed gene editing technology is capable of depleting VEGF2 expression demonstrating a potential therapeutic approach to retinal angiogenesis. The technology, commonly referred to as CRISPR / Cas […]Read full story
Inhibition of soluble epoxide hydrolase (sEH) may slow progression of diabetic retinopathy
Researchers led by investigators at the Institute for Vascular Signaling, Goethe University, Frankfurt, Germany, have identified an enzyme, “soluble epoxide hydrolase” (sEH), to be involved in the loss of pericyte cells and vascular permeability, characteristic of the pathology of diabetic retinopathy. The expression levels of the enzyme were found to be increased in animal models […]Read full story