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Research Articles

Non-responders of anti-VEFG treatments for AMD identify certain genetic variants in the VEGF pathway

Researchers at the Department of Ophthalmology at Ghent University Hospital have reported that the identification of genetic variants from wet AMD patients do not provide benefit for anti-VEFG treatments (ranibizumab and bevacizumab).  The researchers identified several SNPs (single nucleotide polymorphisms) associated with anti-VEFG treatments that did not respond to drug therapy, particularly three genes – […]

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Strategy aims to overcome RP heterogeneity using gene therapy treatment with dominant retinitis pigmentosa

Researchers at the Scheie Eye Institute, University of Pennsylvania, has reported that a mutation-independent strategy for treating autosomal dominant retinitis pigmentosa (adRP) prevents photoreceptor cell death in the retina.  The research team developed a gene therapy approach using a single adeno-associated viral (AAV) system delivering the experimental treatment to a large animal model of RP.  […]

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An international natural history study for patients with RP caused by EYS mutations

Researchers led by Prof. Mark Pennesi M.D., Ph.D., based at the Ophthalmic Genetics Oregon Health & Science University, Portland, USA, has launched a new international natural history study, called “Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS)”.  The study will be funded by the Foundation Fighting Blindness, and will involve 25 centres across the […]

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