Genotype-phenotype correlations in Stargardt disease highlight considerable complexity
Researchers at Radboud University Medical Center, Nijmegen, the Netherlands, have reported that phenotypic divergence between siblings with Stargardt disease (STGD1) carrying the same ABCA4 gene variants underscores the complexity of clinical management. The researchers have identified that fundus autofluorescence phenotypes can be highly comparable between siblings, while functional outcomes can differ substantially. According to the […]Read full story
A systems biology approach aims to build new research activities on non-neovascular age-related macular degeneration.
Researchers at the Wilmer Eye Institute, Johns Hopkins University, Baltimore and the Boston University Schools of Medicine and Public Health, have provided a review paper on how system biology approaches predict disease onset and progression focused on non-vascular or “dry” form of age-related macular degeneration (AMD). These research approaches include genomic, proteomic, metabolomic and other […]Read full story
US National Eye Institute suggests that the innate immune system may be a double-edged sword depending on the context of RP and AMD
Researchers at the National Eye Institute, Bethesda, MD, have demonstrated that C3 and CR3 proteins – components of the human innate immune system – have immunological activity to protect photoreceptor cells in retinitis pigmentosa. The new study shows that the “complement system” (a key biological process for managing normal activity for homeostasis) provides a protective […]Read full story