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Research on research: systematic reviews for retinal and vitreous conditions are classified as not reliable

Researchers at the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, have reported that systematic reviews for retinal and vitreous conditions were deemed to be “as not reliable”.  Just under 60% of systematic reviews were judged to be inadequate and a primary concern indicates that there is a lack of a comprehensive […]

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Research has shown that increased levels of retinol binding protein 3 (RBP3) may protect and treat diabetic retinopathy

Researchers at the Joslin Diabetes Centre, Boston have identified that a protein can protect against diabetic retinopathy (DR) and potentially reverse the effects of complications in mouse models of diabetes.  The level of retinol binding protein 3 (RBP3) expressed in both the vitreous and retina appears to be higher in people who don’t progress to […]

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Genotype-phenotype correlations in Stargardt disease highlight considerable complexity

Researchers at Radboud University Medical Center, Nijmegen, the Netherlands, have reported that phenotypic divergence between siblings with Stargardt disease (STGD1) carrying the same ABCA4 gene variants underscores the complexity of clinical management. The researchers have identified that fundus autofluorescence phenotypes can be highly comparable between siblings, while functional outcomes can differ substantially. According to the […]

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