A clinical research team, based at the Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, Oxford, has published a report on the treatment of RNAi effectors… Read More »Atypical RNA interference effectors – mirtrons – may be applicable for replacement genes treating dominant retinitis pigmentosa (RP).
Researchers led at the Institute for Research in Ophthalmology, Poznan, Poland, have compiled bibliographic data from the 100 most-cited papers on age-related macular degeneration (AMD),… Read More »The 100 most-cited papers on AMD have identified the role of genetics in the pathogenesis of the disease
Researchers based at the Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy, have reported a multicentric longitudinal study with mutations in the CEP290 gene.… Read More »Non-syndromic subjects with mutations in the CEP290 gene have been identified among an Italian cohort of 32 IRD patients
Researchers based at the School of Genetics & Microbiology, Trinity College, Dublin, have reported significant progress on next-generation sequencing (NGS) applications on a range of… Read More »Next-generation sequencing strategies have increased the proportion of resolved diagnoses for several IRDs.
Researchers based at the Institute of Ophthalmology, University College London and at the ICORG Clinical Trials Unit, Western Eye Hospital London, have developed a clinical… Read More »A novel clinical retinal imaging tool termed “DARC” – Detection of Apoptosing Retinal Cells – may yield significant benefits for several IRDs.
Researchers based at the Institute of Ophthalmology, University College London, have identified a rare gene variant within RDH12, encoded by the retinal dehydrogenase enzyme functioning… Read More »A rare variant in RDH12 has been linked to autosomal dominant retinitis pigmentosa within a four-generation pedigree.
Researchers based at Otto von Guericke University of Magdeburg and the Center of Behavioral Brain Sciences (CBBS), Germany, have reported results on siRNA treatment to… Read More »A novel apoptotic strategy has used siRNA to treat caspase-3 effectors protecting neuronal cells following optic nerve damage
Researchers at the University of Hong Kong have reported that clinicians may need to be aware of special considerations for vulnerable patients with ophthalmic conditions,… Read More »Clinicians consider how COVID19 vaccine rollout may impact outcomes for inflammatory eye disease and autoimmune disorders
Researchers at the Department of Ophthalmology, at the University of Milan, have published the largest molecular study of Italian patients with RP in the literature. … Read More »The largest molecular study of RP in Italy has reported 591 probands with family history and sporadic cases.
A novel research report, published in Ophthalmology Science (Jan. 11th 2021) has identified a genetic association between the MMP9 gene (matrix metalloproteinase-9) and exudative AMD. … Read More »First confirmation of genetic association with MMP9 and exudative age-related macular degeneration (AMD).