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Clinical Articles

Clinical trial outcomes for geographic atrophy provides valuable data from both patient and expert input

Research at the Centre for Public Health, Queen’s University Belfast, UK, has suggested that a core outcome set (COS) of measurements should be used in geographic atrophy (GA) trials.  The core outcome set of measurements are proposed to include patient-reported outcome measures, near visual acuity, reading speed and assessment of the outer retina.  According to […]

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Retinal clinical trials indicate that almost 50% of studies have non-compliance issues

Clinical research has indicated that almost half of trial studies have noncompliance issues, creating negative impact outcomes for research.  A recent study has shown that 54.4% of patients were compliant with completing all study visits while 45.6% of subjects were noncompliant.  Given that trials are a cornerstone to collect patient data in order to build […]

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Phase 1b study of a new anti-VEFG antibody has reported BCVA gains across wet AMD, diabetic macular edema and retinal vein occlusion

A brief clinical update reporting on a new anti-VEGF antibody conjugate polymer (identified as KSI-301) has highlighted visual acuity gains with three indications – wet AMD, diabetic edema and retinal vein occlusion.  The experimental treatment has a novel higher molecular weight antibody moiety -950kDA- considerably larger than other anti-VEGF antibodies (ranibizumab [48kDa] and aflibercept [115kDa]).  […]

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