Clinical Articles

Phase IIa trial recruits first patient for novel therapy directed towards treatment of Stargardt’s disease.

A Phase IIa human study, sponsored by Acucela Inc., based in Seattle, Washington, has announced the recruitment of its first patient to evaluate emixustat hydrochloride in subjects with macular atrophy secondary to Stargardt disease. The experimental small molecule treatment, a visual cycle modulator, will be tested in a multicenter, randomized, blinded study to investigate the […]

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Clinical research indicates beneficial effects of flucinolone acetonide implant on course of diabetic retinopathy.

Research, published in the journal Ophthalmology, has reported that a post hoc analysis of data from the 36-month prospective, randomized FAME A and B Phase III trials in DME patients supports the use of the flucinolone acetonide (FAc) implant. The analysis shows that the controlled delivery corticosteroid slows development and progression of disease and may […]

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Whole exome sequencing (WES) continues to yield significant efficiencies in clinical identification of inherited retinal degenerations.

Research results reported by investigators based at the Department of Genetics & Microbiology, University of Barcelona, Spain, have shown that whole exome sequencing (WES) continues to provide efficient returns in the identification of the genetic diagnosis for a range of inherited retinal disorders. The Spanish research group worked on a cohort of 33 families with […]

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