Clinical Articles

CRISPR gene editing technology may initiate LCA clinical research study for Phase I/II

Clinical research for gene editing technology will be aiming to start a Phase I/II interventional trial to treat Leber congenital amaurosis type 10 (LCA10).  LCA10 is the most common form of a retinal degenerative monogenic disorder caused by mutations in a gene of the centrosomal protein (290kD).  The clinical study plan aims to enrol between […]

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Beneficial effects of retinal gene therapy show continuing treatment over 2-year endpoints

Researchers from the Nuffield Laboratory of Ophthalmology, University of Oxford, UK, demonstrate that clinical data on a choroideremia gene therapy study among 14 UK patients showed that visual acuity improved in the 14 treated eyes over controls (median 4.5 letter gain, versus 1.5 letter loss, P = 0.04), with 6 treated eyes gaining more than […]

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Visual impairment appears to be adversely associated with cognition – the Salisbury Eye Evaluation Study

Researchers from the University of Miami, in collaboration with Johns Hopkins University, demonstrate that vision loss precedes a loss of mental capacity, suggesting that maintaining eye health could protect cognition in older adults. An estimated of 5.4 million US individuals, 71 years or older, have cognitive impairment without dementia. Cognitive impairment leads to a decreased quality […]

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