Research from a retrospective analysis of 10 randomized clinical trials reporting on 390 subjects in investigator-initiated trials found 178 participants (45.6%) were noncompliant, while 212… Read More »Non-compliance in clinical trials of retinal studies report a significant loss-to-follow up on patient numbers
Research at the Centre for Public Health, Queen’s University Belfast, UK, has suggested that a core outcome set (COS) of measurements should be used in… Read More »Clinical trial outcomes for geographic atrophy provides valuable data from both patient and expert input
Clinical research has indicated that almost half of trial studies have noncompliance issues, creating negative impact outcomes for research. A recent study has shown that… Read More »Retinal clinical trials indicate that almost 50% of studies have non-compliance issues
A brief clinical update reporting on a new anti-VEGF antibody conjugate polymer (identified as KSI-301) has highlighted visual acuity gains with three indications – wet… Read More »Phase 1b study of a new anti-VEFG antibody has reported BCVA gains across wet AMD, diabetic macular edema and retinal vein occlusion
A clinical research report, published in the journal Ophthalmology, has found that two leading anti-VEGF treatments had shown beneficial outcomes for DME in a study… Read More »Real world data has reported the comparison outcomes between ranibizumab (Lucentis) and aflibercept (Eylea) for Diabetic Macular Edema (DME)
A clinical research report in the British Journal of Ophthalmology has indicated that the use of pentosan polysulfate sodium (PPS, registered as “Elmiron”, Janssen Pharmaceuticals)… Read More »Pentosan polysulfate sodium (PPS), a treatment for interstitial cystitis, has raised concerns for a contraindication of macular disease on long term effects.
A systematic review and meta-analysis on age-related macular degeneration in Europe has reported an increasing prevalent and incident data until 2050. The analysis of the… Read More »A systematic review and meta-analyses shows the prevalent and incidence of age-related macular degeneration in Europe
Researchers at the Department of Ophthalmology, Zealand University Hospital, Denmark, showed that peripheral changes in UWFI (ultra-widefield imaging) were found to be highly prevalent in… Read More »A systematic review with meta-analyses showed peripheral retinal lesions in eyes with AMD using ultra-widefield imaging
A Phase II study investigating intravitreal pegcetacoplan for the treatment of geographic atrophy (GA), secondary to age-related macular degeneration (AMD), has announced the reporting of… Read More »Phase II study results on intravitreal (IVT) pegcetacoplan (a synthetic cyclic peptide) for the treatment of geographic atrophy (GA) secondary to ARMD
Researchers at the Helsinki Retina Research Group at the University of Helsinki, Finland report that while two treatment protocols – either moderate or rapid extensions… Read More »Two different treat-and-extend protocols with aflibercept in wet AMD suggest fewer injections