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Market/Novel Tech

Stealth Biotherapeutics intiates Phase I study with a novel compound targeting mitochondrial dysfunction in retinal disorders.

Stealth Biotherapeutics Inc., a biotechnology company based in Newtown, Massachusetts, have announced the initation of a Phase I study in AMD to test the safety and tolerability of a water-soluble tetrapeptide, “elamipretide”, a compound designed to target mitochondrial dysfunction. The study, named “ReCLAIM”, is an open-label study evaluating 12 weeks of treatment with daily subcutaneous […]

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Phase IIb study of a combination therapy, comprising anti-PDGF and anti-VEGF treatments, show a 62% relative benefit over monotherapy alone

Results of a Phase IIb clinical study, published in the American Journal of Ophthalmology (Ophthalmology, in press), report a 62% relative benefit for the combined use of 1.5 mg “E10030”, an antagonist of platelet derived growth factor (PDGF), and anti-VEGF agent in the treatment of neovascular AMD. The study, sponsored by Ophthotech Corporation, additionally reports a […]

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Research

“Deep learning” algorithm from Google demonstrates high sensitivity and specificity in diabetic retinopathy screening.

A research paper produced by a team of Google Inc. scientists, published in the Journal of the American Medical Association, has claimed that a “deep learning” computer machine algorithm, adapted to screen retinal fundus images, can detect referable diabetic retinopathy with a sensitivity and specificity significantly beyond the 80% sensitivity and specificity recommended by most […]

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Introduction

December 5th, 2016: “EURETINA-Brief”© Issue No. 145

by Dr. Gearóid Tuohy   Dear EURETINA Members,   A very warm welcome to the December 5th, 2016 edition of EURETINA’s web-based digital magazine, “EURETINA Brief”. EURETINA are delighted to continue our delivery of up-to-date summary briefs on a range of topics of interest to retinal clinicians, specialists and researchers across Europe. This resource is […]

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Findings from an international genomics consortium almost double the number of associated genetic loci and variants for AMD

Research conducted by the International AMD Genomics Consortium (IAMDGC) has recently reported an almost doubling in the number of genetic risk loci associated with age-related macular degeneration (AMD). In a significant publication in the journal Nature Genetics, the research group has reported on an analysis of >12 million gene variants, “including 163,714 directly genotyped, mostly […]

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Introduction

January 18th, 2016: “EURETINA-Brief”© Issue No. 125

by Dr. Gearóid Tuohy   Dear EURETINA Members,   A very warm welcome to the January 18th, 2016 edition of EURETINA’s web-based digital magazine, “EURETINA Brief”. EURETINA are delighted to continue our delivery of up-to-date summary briefs on a range of topics of interest to retinal clinicians, specialists and researchers across Europe. This resource is […]

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