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Editas Medicine Inc. (NASDAQ:EDIT), and Allergan plc (NYSE:AGN) aims to dose first LCA10 patients for CRISPR gene therapy in Q1 2020
Editas Medicine, Inc. (NASDAQ: EDIT), based in Dublin, Ireland and Cambridge, Massachusetts, and Allergan plc (NYSE: AGN), also headquartered in Dublin, Ireland have announced that the first potential patient has been successfully screened to administer EDIT-101 by early 2020. “EDIT-101” is a CRISPR-based technology for the treatment of Leber Congenital Amaurosis type 10 (LCA10). CRISPR […]Read full story
Pentosan polysulfate sodium (PPS), a treatment for interstitial cystitis, has raised concerns for a contraindication of macular disease on long term effects.
A clinical research report in the British Journal of Ophthalmology has indicated that the use of pentosan polysulfate sodium (PPS, registered as “Elmiron”, Janssen Pharmaceuticals) is now associated with a new diagnosis of macular disease at a seven-year follow-up in a large retrospective matched cohort study. PPR / Elmiron is marketed for the treatment of […]Read full story
A research study of Stargardt disease (STGD1) highlights inter-sibling variability between genotype-phenotype
Research at the Radboud University Medical Centre in Nijmegen, the Netherlands, has reported a phenotypic discordance between siblings with STGD1 having the same ABCA4 variants. While fundus autofluorescence images appear to compare phenotypic outcomes between siblings, the study identifies substantially different functional outcomes. The research study may throw up significant challenges for clinical management and […]Read full story
December 2nd, 2019: “EURETINA-Brief”© Issue No. 203
by Dr. Gearóid Tuohy Dear EURETINA Members, A very warm welcome to the December 2nd, 2019 edition of EURETINA’s web-based digital magazine, “EURETINA Brief”. EURETINA are delighted to continue our delivery of up-to-date summary briefs on a range of topics of interest to retinal clinicians, specialists and researchers across Europe. This resource is […]Read full story
Genetics and Genomics of Eye Disease, 1st Edition – Advancing to Precision Medicine (Elsevier) Editors: Xiaoyi Gao Ph.D.
Genetics and Genomics of Eye Disease, 1st Edition – Advancing to Precision Medicine (Elsevier) Editors: Xiaoyi Gao Paperback ISBN: 9780128162224 eBook ISBN: 9780128167274; Pages 383, Academic Press, Published Date: 13th September 2019 Medicine has made enormous strides in the 33 years since Tom Roderick, Victor McKusick and Frank Ruddle coined the term “genomics”, outlined […]Read full story
Five-year outcomes of retinal vein occlusion provide long term data for anti-VEGF treatments on real-world data
Researchers at the Sydney Institute of Vision Science, in New South Wales, Australia report that good long-term efficacy of anti-VEGF therapy over 5 years provides a real-world setting, albeit different to the outcome data reported from clinical trial publications. In follow-up to real-world 5-year outcome data on a retrospective population, the results indicate that a […]Read full story