Clinical

A clinical research report in the British Journal of Ophthalmology has indicated that the use of pentosan polysulfate sodium (PPS, registered as “Elmiron”, Janssen Pharmaceuticals)… Read More »Pentosan polysulfate sodium (PPS), a treatment for interstitial cystitis, has raised concerns for a contraindication of macular disease on long term effects.

A systematic review and meta-analysis on age-related macular degeneration in Europe has reported an increasing prevalent and incident data until 2050. The analysis of the… Read More »A systematic review and meta-analyses shows the prevalent and incidence of age-related macular degeneration in Europe

Researchers at the Department of Ophthalmology, Zealand University Hospital, Denmark, showed that peripheral changes in UWFI (ultra-widefield imaging) were found to be highly prevalent in… Read More »A systematic review with meta-analyses showed peripheral retinal lesions in eyes with AMD using ultra-widefield imaging

A Phase II study investigating intravitreal pegcetacoplan for the treatment of geographic atrophy (GA), secondary to age-related macular degeneration (AMD), has announced the reporting of… Read More »Phase II study results on intravitreal (IVT) pegcetacoplan (a synthetic cyclic peptide) for the treatment of geographic atrophy (GA) secondary to ARMD

Researchers at the Helsinki Retina Research Group at the University of Helsinki, Finland report that while two treatment protocols – either moderate or rapid extensions… Read More »Two different treat-and-extend protocols with aflibercept in wet AMD suggest fewer injections

Researchers at the NIH, National Eye Institute, Bethesda have reported a phase I/IIa study on the use of an AAV8 vector for ocular gene delivery… Read More »Retinal gene therapy for X-linked retinoschisis showed that AAV8 treatment had positive safety and tolerability outcomes

Researchers at the Institute of Molecular and Clinical Ophthalmology Basel, Switzerland (a consortium led by the ProgStar Study Group) have reported that autofluorescence imaging in… Read More »A progression of Stargardt disease can assess autofluorescence over a 12-month clinical research study.

Researchers at the Scheie Eye Institute, University of Pennsylvania, Philadelphia, has published a systematic review to assess the key design characteristics of geographic atrophy (GA)… Read More »A systematic review of registered trials in ClinicalTrials.gov shows the characteristics of geographic atrophy treatment trials

A combination of two European population-based prospective cohorts has carried out the investigation on the adherence to a Mediterranean diet (“MeDi”).  The adherence to the… Read More »A prospective study of 5,000 participants indicates that a Mediterranean diet has a 41% reduced risk of incidence of advanced AMD

A systematic review and meta-analysis, published by British Medical Journal Open (2019), has included 19 randomized controlled trials (RCTs) to evaluate the comparative effectiveness and… Read More »Clinical research for systematic reviews and meta-analysis focuses on cn-AMD, DMO, RVO-MO and m-CNV