New miniature pig model mimics the most common form of dominant retinitis pigmentosa in humans

A consortium of researchers, led by Iowa State University & the University of Louisville, have reported the successful generation of a new large animal model for use in the development of new therapies to treat retinal degenerative disease. The miniature-pig model, harbouring the Pro23His rhodopsin mutation, was created by somatic cell nuclear transfer (SCNT) and is described in detail in a publication in Investigative Ophthalmology & Visual Science (2012, 53, 1, 501-507). The model is expected to provide a significant research tool to the increasing numbers of translational research projects aiming to progress new therapies to the clinic.