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Market/Novel Tech

Advernum and Editas join forces to explore applications of gene editing to ocular disease.

Adverum Biotechnologies, Inc. (NASDAQ:ADVM), previously Avalanche Biotechnologies Inc., and Editas Medicine, Inc. (NASDAQ:EDIT) have announced a collaboration to employ gene editing technology (CRISPR) in the treatment of up to five inherited retinal disorders. The companies will aim to use their complimentary strengths in delivery and gene-editing to tackle major opportunities in the gene therapy field. […]

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Featured

Phase III clinical trial results with gene therapy AAV delivered RPE-65 show functional and sensitivity improvements.

A clinical study on a small number of patients with retinal degeneration cause by RPE-65 mutations, has reported positive results in respect of visual function and full-field sensitivity testing. An adeno-associated viral vector carrying engineered versions of the RPE-65 gene, manufactured by Spark Therapeutics (NASDAQ: ONCE) in the US and referenced as voretigene neparvovec, is […]

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Research

Mind the gap – results may differ: conference highlights difference between clinical practice and clinical trials with anti-VEGF therapies

Results of real world clinical practice with anti-VEGF treatments, presented at this year’s American Society of Retina Specialists (ASRS) 2016 Annual Meeting, highlighted a considerable gap between clinicians’ day-to-day experience and the results of clinical trials used to secure marketing authorisation. The findings, from a review of 750,000 patients, possibly represent the largest such study […]

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Introduction

August 18th, 2016: “EURETINA-Brief”© Issue No. 138

by Dr. Gearóid Tuohy   Dear EURETINA Members,   A very warm welcome to the August 18th, 2016 edition of EURETINA’s web-based digital magazine, “EURETINA Brief”. EURETINA are delighted to continue our delivery of up-to-date summary briefs on a range of topics of interest to retinal clinicians, specialists and researchers across Europe. This resource is […]

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Findings from an international genomics consortium almost double the number of associated genetic loci and variants for AMD

Research conducted by the International AMD Genomics Consortium (IAMDGC) has recently reported an almost doubling in the number of genetic risk loci associated with age-related macular degeneration (AMD). In a significant publication in the journal Nature Genetics, the research group has reported on an analysis of >12 million gene variants, “including 163,714 directly genotyped, mostly […]

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Introduction

January 18th, 2016: “EURETINA-Brief”© Issue No. 125

by Dr. Gearóid Tuohy   Dear EURETINA Members,   A very warm welcome to the January 18th, 2016 edition of EURETINA’s web-based digital magazine, “EURETINA Brief”. EURETINA are delighted to continue our delivery of up-to-date summary briefs on a range of topics of interest to retinal clinicians, specialists and researchers across Europe. This resource is […]

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