Researchers based at the North Texas Eye Research Institute and the University of Alabama have reported that targeting of a component in a well-researched cellular stress response mechanism may represent a possible mechanism for interfering with angiogenesis. The research, published in the journal IOVS (Invest Ophthalmol Vis Sci. 2013; 54:5995-6002; DOI:10.1167/iovs.13-12117), showed that inhibition of the transcription factor ATF4 may provide a prospective therapeutic target to inhibit neovascularization in a range of proliferative retinopathies.