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Genetic manipulation of angiogenesis may present new therapeutic targets for neovascularization diseases

Researchers based at the North Texas Eye Research Institute and the University of Alabama have reported that targeting of a component in a well-researched cellular stress response mechanism may represent a possible mechanism for interfering with angiogenesis. The research, published in the journal IOVS (Invest Ophthalmol Vis Sci. 2013; 54:5995-6002; DOI:10.1167/iovs.13-12117), showed that inhibition of the transcription factor ATF4 may provide a prospective therapeutic target to inhibit neovascularization in a range of proliferative retinopathies.