A consortium of research groups, headed by Dr. Jimena Rojas of the University of Valladolid, Spain, has shown that four specific genes are associated with the development of proliferative vitreoretinopathy (PVR). The finding, in a population of patients under-going retinal detachment surgery, could open significant new lines of research into the molecular biology of PVR and aid in identifying novel therapeutic targets. As PVR continues to represent a major cause of failure in retinal detachment (RD) surgery there is keen interest in reducing the burden of the complication world-wide.