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Gastric-acid medication may induce and enhance visual hallucinations in macular degeneration patients

Joint research work, conducted at the Scripps Research Institute, La Jolla, California and the University of Nebraska Medical Center, suggests that certain proton pump inhibitor medication, including lansoprazole, omeprazole and pantoprazole, may enhance visual hallucinations in macular degeneration patients. The research, funded by the US National Institutes of Health (NIH) and published in the journal Investigative Ophthalmology & Visual Science (IOVS, 2013; 54:1485-1489), suggests that patterned visual hallucinations may be induced or enhanced in wet AMD patients that use some types of gastric acid medication. The authors of the study propose that proton pump inhibitors may disrupt normal horizontal cell-photoreceptor cell feedback interactions leading to alterations in spatial and chromatic perception.