Research reported in the open access journal, PLoS One (Vol. 6, Iss. 5, e20326), suggests that intravitreal injection of CNTF (ciliary neurotrophic factor) into murine eyes induces the remodelling of gene expression profiles. The findings from analysis of Muller cells showed that there was expression of a variety of genes in networks associated with transcription, cell cycle regulation and inflammatory response following CNTF treatment. In addition, the neurotrophic factor also appeared to induce gliosis in the retina. The research provides important insights into the biology of CNTF administration in murine tissues.