by Dr. Gearóid Tuohy
Dear EURETINA Members,
A very warm welcome to the September 6th, 2015 edition of EURETINA’s web-based digital magazine, “EURETINA Brief”. EURETINA are delighted to continue our delivery of up to date summary briefs on a range of topics of interest to retinal specialists and researchers across Europe. This resource is designed to accommodate the very busy schedules of all our members by providing them with a short overview of some new developments and announcements in our field over recent weeks.
As in previous issues we have incorporated a feedback section where you can comment on any of the news items or articles under discussion and we very much welcome all contributions. Previous articles and issues can be found in the archive section on the left hand panel.
The current issue highlights a number of research activities, clinical milestones and business developments in our field, including research from Wayne State University, Michigan, showing that mitochondrial DNA methylation may be regulated with siRNA to restore mitochondrial homeostasis in diabetic retinopathy; publication of advice for clinicians from Canada’s University of Alberta on how best to manage communications with patients regarding novel gene therapy technologies, and finally; an announcement from the publicly listed company, StemCells Inc., in California, on the dosing of a first patient with purified human neural stem cells directed at the treatment of geographic atrophy (GA).
Finally, our feature bio-ophthalmology article reports on US-based research highlighting the rescue of a retinal degeneration by the reprogramming of rods into cones. The study used a well-characterized retinal transcription factor to re-direct rods to a cone cell fate. The result of the cellular reprogramming reduced rod photoreceptor cell death in a rhodopsin knock-out model of retinitis pigmentosa (RP). The results of the research, notwithstanding the loss of rod cell function and potential consequent night-blindness, suggest that maintaining a rod photoreceptor cell architecture may be sufficient to slow or halt cone cell degeneration.
As always, increased interaction by you with the EURETINA web community serves to expand your professional network and keep you up to date with the latest initiatives, activities and research in your field. Our hope is that such cross-fertilisation in an active web-based platform will lead to increased collaborative opportunities and ultimately to improved patient care. All readers are invited to submit comments or responses to any of the stories featured and we look forward to hearing from you over the coming month.
Dr. Gearóid Tuohy, EURETINA