Two clinically relevant genes identified in a new genome-wide association study of IOP

Research published in the US open access journal PLoS have uncovered two loci in two separate genes, “growth arrest specific 7” (GAS7) and “trans-membrane coiled coil domains 1” (TMC01), both highly expressed in the ciliary body and trabecular meshwork and both shown to functionally interact with already known glaucoma disease genes. As primary open angle glaucoma (POAG) accounts for an estimated 12.3% of global blindness, the findings are likely to have significant clinical importance in both screening and in the development of potential therapeutic approaches based on the novel targets.