EMA has advised that the use of ibuprofen for COVID19 treatment will be monitored.

The EMA (European Medicines Agency) has issued a formal statement following a comment from France’s Health Minister, Oliver Veran, suggesting that patients with COVID19 symptoms should using paracetamol rather than ibuprofen.  The comment, issued on Twitter, advised that, “Taking anti-inflammatory drugs (ibuprofen, cortisone…) could be an aggravating factor for the infection. If you have a fever, take paracetamol”.  Following the media from national and international outlets, the EMA stated that, “There is currently no scientific evidence establishing a link between ibuprofen and worsening of COVID-19. EMA is monitoring the situation closely and will review any new information that becomes available on this issue in the context of the pandemic”.

 

A list of national competent agencies2 and relevant national bodies can be reviewed across Member States.  In the Irish “Heath Service Executive” (HSE), their website advised that, “It is okay to take anti-inflammatories (NSAID) if you have coronavirus. There is no evidence that they are unsafe. Only take one anti-inflammatory medication at a time. It is okay to take paracetamol and an anti-inflammatory like ibuprofen at the same time”.  In the UK, the Medicines and Healthcare products Regulatory Agency” (MHRA) stated that, “There is some debate suggesting NSAIDs may increase complications from simple acute respiratory infections or slow recovery. The product information of many NSAIDs already contains warnings that their anti-inflammatory effects may hide the symptoms of a worsening infection. However the evidence is not conclusive.  In view of the current lack of research the Commission on Human Medicines (an expert advisory body of MHRA) and NICE have been asked to review the evidence.

 

At the EMA, an original concern on ibuprofen led to a review of NSAIDs (ibuprofen and ketoprofen) in May 2019, following a survey by the French National Agency for Medicines and Health Products Safety (ANSM).  Their survey suggested that infection due to “chickenpox (varicella) and some bacterial infections could be made worse by these medicines”. In addition, Paul Little, a professor of primary care research at the University of Southampton, UK, said that there was good evidence “that prolonged illness or the complications of respiratory infections may be more common when NSAIDs are used—both respiratory or septic complications and cardiovascular complications.” He added, “The finding in two randomised trials that advice to use ibuprofen results in more severe illness or complications helps confirm that the association seen in observational studies is indeed likely to be causal. Advice to use paracetamol is also less likely to result in complications.”  If any new information arises on this data, it will be circulated at both the EMA and other relevant heath agencies.

 

  1. https://www.ema.europa.eu/en/partners-networks/eu-partners/eu-member-states/national-competent-authorities-human

377 thoughts on “EMA has advised that the use of ibuprofen for COVID19 treatment will be monitored.”

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  120. When I originally commented I seem to have clicked the -Notify me when new comments are added- checkbox and now each time a comment is added I receive 4 emails with the exact same comment. Is there a means you can remove me from that service? Kudos!

  121. Greetings! Very useful advice in this particular post! It is the little changes which will make the greatest changes. Many thanks for sharing!

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  134. When I originally left a comment I appear to have clicked the -Notify me when new comments are added- checkbox and now every time a comment is added I receive 4 emails with the exact same comment. Is there an easy method you can remove me from that service? Thanks a lot!

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  142. When I originally left a comment I appear to have clicked on the -Notify me when new comments are added- checkbox and now every time a comment is added I receive 4 emails with the same comment. Perhaps there is an easy method you can remove me from that service? Thanks a lot!

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  154. I absolutely love your blog.. Great colors & theme. Did you develop this web site yourself? Please reply back as I’m planning to create my own personal site and want to learn where you got this from or just what the theme is named. Thank you!

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  165. May I simply just say what a comfort to uncover someone that genuinely knows what they are discussing over the internet. You certainly know how to bring a problem to light and make it important. More and more people must read this and understand this side of your story. It’s surprising you aren’t more popular since you surely possess the gift.

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  170. Hello! I just wanted to ask if you ever have any problems with hackers? My last blog (wordpress) was hacked and I ended up losing many months of hard work due to no back up. Do you have any solutions to protect against hackers?

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  175. I do trust all of the ideas you’ve introduced for your post. They’re very convincing and will certainly work. Still, the posts are very short for newbies. Could you please prolong them a little from next time? Thank you for the post.

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  177. Howdy! This blog post couldn’t be written much better! Looking through this article reminds me of my previous roommate! He always kept preaching about this. I will forward this post to him. Pretty sure he’ll have a good read. Thanks for sharing!

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  179. Oh my goodness! Amazing article dude! Thank you so much, However I am experiencing troubles with your RSS. I don’t know why I cannot subscribe to it. Is there anybody having the same RSS problems? Anybody who knows the solution can you kindly respond? Thanx!!

  180. An outstanding share! I’ve just forwarded this onto a colleague who had been conducting a little research on this. And he actually bought me dinner because I found it for him… lol. So allow me to reword this…. Thank YOU for the meal!! But yeah, thanks for spending the time to talk about this issue here on your internet site.

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  182. After I originally left a comment I seem to have clicked the -Notify me when new comments are added- checkbox and now whenever a comment is added I recieve 4 emails with the exact same comment. Is there an easy method you are able to remove me from that service? Kudos!

  183. I seriously love your website.. Great colors & theme. Did you build this amazing site yourself? Please reply back as I’m hoping to create my very own site and want to find out where you got this from or exactly what the theme is named. Thanks!

  184. An intriguing discussion is worth remark. I assume that you should write more on this subject, it could not be a taboo subject but typically individuals are insufficient to talk on such subjects. To the following. Cheers

  185. I’m impressed, I have to admit. Rarely do I encounter a blog that’s equally educative and engaging, and let me tell you, you’ve hit the nail on the head. The problem is something which not enough people are speaking intelligently about. I am very happy that I came across this during my search for something regarding this.

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  189. Hi, I do think this is an excellent website. I stumbledupon it 😉 I will return yet again since i have book-marked it. Money and freedom is the best way to change, may you be rich and continue to guide others.

  190. Greetings! Very useful advice in this particular article! It is the little changes that will make the most significant changes. Thanks for sharing!

  191. You have made some really good points there. I checked on the net for more information about the issue and found most individuals will go along with your views on this site.

  192. I’m impressed, I have to admit. Rarely do I encounter a blog that’s both educative and entertaining, and let me tell you, you’ve hit the nail on the head. The issue is an issue that not enough people are speaking intelligently about. I am very happy I came across this in my search for something regarding this.

  193. Can I simply say what a comfort to discover someone who really understands what they’re discussing online. You certainly realize how to bring an issue to light and make it important. More people have to check this out and understand this side of the story. I was surprised that you are not more popular given that you certainly possess the gift.

  194. An impressive share! I’ve just forwarded this onto a co-worker who was conducting a little research on this. And he in fact ordered me breakfast simply because I found it for him… lol. So allow me to reword this…. Thank YOU for the meal!! But yeah, thanx for spending time to talk about this issue here on your web page.

  195. The next time I read a blog, I hope that it doesn’t fail me as much as this particular one. I mean, I know it was my choice to read, but I actually believed you would probably have something interesting to talk about. All I hear is a bunch of crying about something that you could possibly fix if you were not too busy searching for attention.

  196. The next time I read a blog, Hopefully it doesn’t disappoint me as much as this one. I mean, I know it was my choice to read, but I actually thought you would probably have something interesting to say. All I hear is a bunch of crying about something that you can fix if you were not too busy looking for attention.

  197. Howdy! I simply wish to give you a huge thumbs up for the great information you have got right here on this post. I’ll be returning to your web site for more soon.

  198. I’m impressed, I must say. Seldom do I come across a blog that’s both equally educative and engaging, and without a doubt, you’ve hit the nail on the head. The problem is something which too few men and women are speaking intelligently about. I’m very happy I stumbled across this during my hunt for something regarding this.

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