Researchers based at Kagoshima University’s Department of Ophthalmology in Japan have shown that OCT (optical coherence tomography) measures of reflectivity may be correlated with vascular permeability or intravitreous VEGF concentration. The finding may be used to provide a novel replacement assay to the more traditional invasive fluorescent angiography used in clinical diagnosis and prognoses following retinal treatments. Examination of eyes affected by diabetic macular edema (DME) showed that OCT reflectivity of sub-retinal fluid was correlated significantly with intravitreal VEGF, potentially allowing clinicians to obtain both quantitative morphologic information and qualitative insight in a non-invasive manner.