A promising treatment – Remdesivir – is now progressing a clinical trial for COVID19 supported by the National Institutes of Health

Multiple clinical trials are now in progress aimed at developing COVID19 vaccines, repurposing drugs or new treatments running across the US, Canada, Europe and China.  Programmes include large multinational pharma companies such as GSK and Sanofi, mid-sized biotech companies such Gilead and Moderna, and academic organisations, supported by, for example, government funding, the Wellcome Trust, or the Bill and Melinda Gates Fund.  As of writing, there are almost 250 COVID19/coronavirus clinical trials listed at the EMA and/or Clinicaltrials.gov.

 

One of the more promising studies in development from Gilead Sciences Inc., is “Remdesivir”, supported at the NIH evaluating patients at the University of Nebraska Medical Center in Omaha.  The randomized, controlled clinical trial aims to evaluate the safety and efficacy of the investigational antiviral treatment in hospitalized adults diagnosed with coronavirus disease 2019 (COVID-19).  Participants in the NIH-sponsored trial must have laboratory-confirmed SARS-CoV-2 infection and evidence of lung involvement, including rattling sounds when breathing with a need for supplemental oxygen or abnormal chest X-rays, or illness requiring mechanical ventilation. Individuals with confirmed infection who have mild, cold-like symptoms or no apparent symptoms will not be included in the study. In accordance with standard clinical research protocols, eligible patients will provide informed consent to participate in the trial.  More information from Clinicaltrials.gov is listed under NCT04280705.

 

The trial regulatory sponsor is the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health and this is the first clinical trial in the United States to evaluate an experimental treatment, the respiratory disease first detected in December 2019 in Wuhan, Hubei Province, China.  According to the NIH, the first trial participant is an American repatriated after being quarantined on the Diamond Princess cruise ship that docked in Yokohama, Japan who volunteered to participate in the study. The study drug is (Remdesivir), a single diastereomer monophosphoramidate prodrug designed for the intracellular delivery of a modified adenine nucleoside analog GS-441524.  200 mg of the Remdesivir administered intravenously on Day 1, followed by a 100 mg once-daily maintenance dose for the duration of the hospitalization up to a 10 days total course.  The NIAID Director and U.S. Coronavirus Task Force member Anthony S. Fauci, M.D. stated, “We urgently need a safe and effective treatment for COVID-19. Although Remdesivir has been administered to some patients with COVID-19, we do not have solid data to indicate it can improve clinical outcomes. A randomized, placebo-controlled trial is the gold standard for determining if an experimental treatment can benefit patients.”

548 thoughts on “A promising treatment – Remdesivir – is now progressing a clinical trial for COVID19 supported by the National Institutes of Health”

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  119. I seriously love your website.. Very nice colors & theme. Did you build this website yourself? Please reply back as I’m hoping to create my own site and would like to learn where you got this from or exactly what the theme is named. Cheers!

  120. I’m excited to uncover this great site. I want to to thank you for your time due to this fantastic read!! I definitely savored every little bit of it and I have you bookmarked to see new stuff in your website.

  121. May I just say what a relief to find somebody that truly understands what they are discussing on the net. You actually realize how to bring a problem to light and make it important. More and more people have to check this out and understand this side of your story. I was surprised that you’re not more popular because you surely possess the gift.

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  123. Your style is so unique in comparison to other folks I’ve read stuff from. Thanks for posting when you have the opportunity, Guess I’ll just book mark this page.

  124. I discovered your blog site on google and check a few of your early articles. Continue to maintain the great operate. I simply additional up your RSS feed to my MSN Information Viewers. Looking for ahead to reading more from you in the future!?

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  126. Hi, I do believe your site might be having browser compatibility problems. When I look at your site in Safari, it looks fine however when opening in I.E., it has some overlapping issues. I simply wanted to give you a quick heads up! Other than that, great website!

  127. Hi there! This post could not be written much better! Reading through this article reminds me of my previous roommate! He always kept preaching about this. I most certainly will forward this post to him. Fairly certain he’s going to have a good read. I appreciate you for sharing!

  128. Having read this I believed it was very enlightening. I appreciate you spending some time and energy to put this informative article together. I once again find myself spending way too much time both reading and leaving comments. But so what, it was still worth it!

  129. Hi, I do believe this is a great website. I stumbledupon it 😉 I will revisit once again since I book marked it. Money and freedom is the greatest way to change, may you be rich and continue to guide others.

  130. I blog frequently and I really thank you for your information. The article has truly peaked my interest. I will take a note of your website and keep checking for new details about once a week. I subscribed to your Feed as well.

  131. Everything is very open with a very clear clarification of the issues. It was definitely informative. Your website is useful. Many thanks for sharing!

  132. This is a good tip particularly to those fresh to the blogosphere. Simple but very accurate information… Thanks for sharing this one. A must read post!

  133. I wanted to thank you for this very good read!! I absolutely enjoyed every little bit of it. I’ve got you saved as a favorite to check out new stuff you post…

  134. I truly love your site.. Very nice colors & theme. Did you make this web site yourself? Please reply back as I’m attempting to create my own personal site and would love to find out where you got this from or just what the theme is called. Appreciate it!

  135. Your style is very unique compared to other folks I’ve read stuff from. Many thanks for posting when you have the opportunity, Guess I’ll just bookmark this blog.

  136. An outstanding share! I’ve just forwarded this onto a colleague who has been doing a little research on this. And he in fact bought me breakfast due to the fact that I found it for him… lol. So allow me to reword this…. Thanks for the meal!! But yeah, thanks for spending the time to talk about this issue here on your web site.

  137. An outstanding share! I’ve just forwarded this onto a co-worker who had been conducting a little homework on this. And he actually bought me dinner due to the fact that I discovered it for him… lol. So let me reword this…. Thank YOU for the meal!! But yeah, thanx for spending time to talk about this matter here on your website.

  138. This is a great tip particularly to those new to the blogosphere. Short but very accurate information… Thanks for sharing this one. A must read post!

  139. Good day! I could have sworn I’ve visited this web site before but after browsing through a few of the articles I realized it’s new to me. Anyways, I’m certainly happy I stumbled upon it and I’ll be bookmarking it and checking back frequently!

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  142. An interesting discussion is worth comment. I do believe that you should publish more on this subject, it might not be a taboo subject but typically people do not speak about such topics. To the next! Kind regards!!

  143. Good day! I could have sworn I’ve visited this web site before but after looking at some of the articles I realized it’s new to me. Anyways, I’m certainly delighted I came across it and I’ll be book-marking it and checking back frequently!

  144. Your style is really unique in comparison to other people I have read stuff from. I appreciate you for posting when you have the opportunity, Guess I will just book mark this page.

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  146. May I just say what a comfort to discover an individual who actually knows what they are discussing over the internet. You actually know how to bring a problem to light and make it important. A lot more people ought to read this and understand this side of the story. I was surprised you aren’t more popular because you definitely possess the gift.

  147. Hello there! This post couldn’t be written much better! Looking through this article reminds me of my previous roommate! He constantly kept preaching about this. I will forward this article to him. Fairly certain he will have a great read. Many thanks for sharing!

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  151. I must thank you for the efforts you have put in penning this blog. I am hoping to check out the same high-grade content by you later on as well. In truth, your creative writing abilities has motivated me to get my own website now 😉

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  163. Nice post. I learn something totally new and challenging on blogs I stumbleupon everyday. It’s always interesting to read through content from other authors and use a little something from other websites.

  164. I need to to thank you for this great read!! I definitely loved every little bit of it. I have you saved as a favorite to check out new stuff you post…

  165. An impressive share! I have just forwarded this onto a colleague who has been conducting a little research on this. And he actually bought me dinner simply because I stumbled upon it for him… lol. So allow me to reword this…. Thanks for the meal!! But yeah, thanx for spending some time to talk about this matter here on your web site.

  166. Having read this I believed it was rather informative. I appreciate you taking the time and effort to put this content together. I once again find myself spending way too much time both reading and commenting. But so what, it was still worthwhile!

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  168. Hi! I could have sworn I’ve visited this site before but after going through a few of the articles I realized it’s new to me. Nonetheless, I’m certainly pleased I came across it and I’ll be book-marking it and checking back regularly!

  169. Oh my goodness! Incredible article dude! Thank you so much, However I am having difficulties with your RSS. I don’t know why I am unable to join it. Is there anybody having the same RSS problems? Anyone that knows the solution can you kindly respond? Thanks!!

  170. After looking into a number of the articles on your blog, I honestly like your way of blogging. I saved as a favorite it to my bookmark website list and will be checking back soon. Please check out my website as well and let me know how you feel.

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  174. Having read this I believed it was really informative. I appreciate you spending some time and effort to put this information together. I once again find myself personally spending a significant amount of time both reading and posting comments. But so what, it was still worth it!

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  176. Hello there! This post couldn’t be written any better! Looking at this post reminds me of my previous roommate! He always kept preaching about this. I am going to send this article to him. Fairly certain he’s going to have a very good read. Thank you for sharing!

  177. I seriously love your site.. Great colors & theme. Did you make this web site yourself? Please reply back as I’m hoping to create my own personal blog and would love to know where you got this from or just what the theme is named. Cheers!

  178. Aw, this was an extremely nice post. Taking a few minutes and actual effort to generate a great article… but what can I say… I put things off a whole lot and don’t seem to get nearly anything done.

  179. Aw, this was an incredibly nice post. Spending some time and actual effort to create a superb article… but what can I say… I procrastinate a lot and never manage to get nearly anything done.

  180. I think what you said made a bunch of sense.
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  181. Can I simply say what a comfort to discover someone that genuinely understands what they’re discussing over the internet. You certainly understand how to bring an issue to light and make it important. More and more people should look at this and understand this side of your story. I can’t believe you’re not more popular since you certainly possess the gift.

  182. I have to thank you for the efforts you have put in penning this site. I am hoping to view the same high-grade content from you later on as well. In fact, your creative writing abilities has motivated me to get my very own blog now 😉

  183. Hi, I do think this is an excellent site. I stumbledupon it 😉 I am going to return yet again since I book-marked it. Money and freedom is the best way to change, may you be rich and continue to help other people.

  184. Having read this I thought it was very enlightening. I appreciate you spending some time and effort to put this content together. I once again find myself spending a lot of time both reading and commenting. But so what, it was still worthwhile!

  185. I was pretty pleased to discover this page. I wanted to thank you for your time for this particularly wonderful read!! I definitely savored every little bit of it and i also have you book-marked to look at new things on your site.

  186. I seriously love your blog.. Great colors & theme. Did you build this amazing site yourself? Please reply back as I’m hoping to create my very own blog and want to know where you got this from or exactly what the theme is named. Appreciate it!

  187. Amazing blog! Is your theme custom made or did you download it from somewhere?
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  192. I do trust all of the ideas you’ve presented in your post.
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  193. Having read this I believed it was very enlightening. I appreciate you finding the time and energy to put this information together. I once again find myself spending way too much time both reading and posting comments. But so what, it was still worth it!

  194. I want to to thank you for this fantastic read!! I absolutely enjoyed every little bit of it. I’ve got you book marked to look at new things you post…

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  196. I’m amazed, I must say. Seldom do I come across a blog that’s both equally educative and amusing, and without a doubt, you’ve hit the nail on the head. The problem is something which too few men and women are speaking intelligently about. Now i’m very happy that I came across this during my hunt for something concerning this.

  197. Nice weblog here! Additionally your site loads up fast!
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  198. May I simply say what a comfort to discover someone that truly knows what they’re talking about on the web. You definitely know how to bring a problem to light and make it important. More people ought to check this out and understand this side of the story. I was surprised that you aren’t more popular given that you definitely have the gift.

  199. An outstanding share! I’ve just forwarded this onto a colleague who was doing a little research on this. And he actually bought me dinner simply because I stumbled upon it for him… lol. So let me reword this…. Thank YOU for the meal!! But yeah, thanks for spending time to talk about this issue here on your site.

  200. Having read this I thought it was really informative. I appreciate you spending some time and energy to put this short article together. I once again find myself personally spending way too much time both reading and posting comments. But so what, it was still worthwhile!

  201. I’m impressed, I must say. Seldom do I encounter a blog that’s both equally educative and entertaining, and without a doubt, you’ve hit the nail on the head. The problem is something which too few men and women are speaking intelligently about. I’m very happy that I found this in my search for something relating to this.

  202. Having read this I believed it was rather informative. I appreciate you spending some time and effort to put this information together. I once again find myself spending a lot of time both reading and leaving comments. But so what, it was still worth it!

  203. Hello there! I could have sworn I’ve visited this site before but after looking at a few of the posts I realized it’s new to me. Anyhow, I’m certainly happy I stumbled upon it and I’ll be bookmarking it and checking back frequently!

  204. I’m impressed, I have to admit. Seldom do I encounter a blog that’s both educative and entertaining, and let me tell you, you’ve hit the nail on the head. The problem is something not enough folks are speaking intelligently about. Now i’m very happy I found this during my hunt for something relating to this.

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  208. After I initially commented I appear to have clicked on the -Notify me when new comments are added- checkbox and now every time a comment is added I recieve 4 emails with the exact same comment. Is there a way you are able to remove me from that service? Cheers!

  209. This is a very good tip particularly to those fresh to the blogosphere. Short but very accurate info… Appreciate your sharing this one. A must read post!

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  214. May I simply just say what a relief to find someone that genuinely knows what they are discussing on the net. You definitely realize how to bring a problem to light and make it important. A lot more people really need to check this out and understand this side of the story. It’s surprising you aren’t more popular because you certainly have the gift.

  215. Hi, I do believe your web site may be having internet browser compatibility issues. When I look at your website in Safari, it looks fine however, if opening in IE, it’s got some overlapping issues. I merely wanted to give you a quick heads up! Other than that, wonderful site!

  216. You’re so awesome! I don’t think I’ve read through something like this before. So great to find somebody with some genuine thoughts on this topic. Seriously.. many thanks for starting this up. This website is something that’s needed on the internet, someone with some originality!

  217. An impressive share! I’ve just forwarded this onto a colleague who was doing a little research on this. And he in fact bought me breakfast due to the fact that I discovered it for him… lol. So allow me to reword this…. Thanks for the meal!! But yeah, thanx for spending the time to discuss this subject here on your site.

  218. An impressive share! I’ve just forwarded this onto a co-worker who has been conducting a little homework on this. And he in fact bought me lunch because I discovered it for him… lol. So let me reword this…. Thank YOU for the meal!! But yeah, thanks for spending some time to talk about this issue here on your internet site.

  219. Aw, this was an exceptionally good post. Spending some time and actual effort to generate a great article… but what can I say… I put things off a whole lot and don’t seem to get nearly anything done.

  220. Having read this I thought it was extremely informative. I appreciate you spending some time and energy to put this article together. I once again find myself personally spending way too much time both reading and leaving comments. But so what, it was still worthwhile!

  221. Can I just say what a comfort to find a person that really knows what they’re talking about on the web. You certainly know how to bring an issue to light and make it important. A lot more people should check this out and understand this side of your story. I was surprised you’re not more popular given that you definitely have the gift.

  222. Oh my goodness! Impressive article dude! Thank you, However I am experiencing issues with your RSS. I don’t know why I am unable to subscribe to it. Is there anyone else getting the same RSS problems? Anyone who knows the solution will you kindly respond? Thanks!!

  223. Hi, I do think this is an excellent website. I stumbledupon it 😉 I’m going to return yet again since I saved as a favorite it. Money and freedom is the best way to change, may you be rich and continue to help others.

  224. Aw, this was an exceptionally good post. Taking the time and actual effort to create a good article… but what can I say… I hesitate a lot and never seem to get nearly anything done.

  225. Having read this I thought it was extremely informative. I appreciate you taking the time and effort to put this content together. I once again find myself spending a lot of time both reading and commenting. But so what, it was still worthwhile!

  226. Hello there! This article couldn’t be written any better! Looking at this article reminds me of my previous roommate! He always kept preaching about this. I am going to forward this post to him. Pretty sure he will have a very good read. Many thanks for sharing!

  227. I’m amazed, I must say. Seldom do I encounter a blog that’s equally educative and engaging, and let me tell you, you have hit the nail on the head. The problem is something not enough men and women are speaking intelligently about. I am very happy I found this in my search for something concerning this.

  228. An outstanding share! I have just forwarded this onto a co-worker who has been doing a little research on this. And he actually ordered me dinner due to the fact that I discovered it for him… lol. So let me reword this…. Thank YOU for the meal!! But yeah, thanx for spending time to discuss this matter here on your web site.

  229. May I just say what a comfort to discover someone that truly knows what they are discussing on the web. You certainly know how to bring an issue to light and make it important. More people should check this out and understand this side of the story. It’s surprising you aren’t more popular since you most certainly have the gift.

  230. After I initially left a comment I seem to have clicked on the -Notify me when new comments are added- checkbox and now whenever a comment is added I receive four emails with the same comment. Is there an easy method you are able to remove me from that service? Many thanks!

  231. That is a good tip particularly to those new to the blogosphere. Brief but very accurate info… Thank you for sharing this one. A must read post!

  232. Good post. I learn something totally new and challenging on websites I stumbleupon every day. It’s always useful to read through articles from other writers and practice something from other websites.

  233. May I simply just say what a comfort to discover someone who truly understands what they are talking about on the internet. You certainly understand how to bring an issue to light and make it important. More people must look at this and understand this side of the story. I can’t believe you’re not more popular given that you certainly have the gift.

  234. Hi, I do think this is an excellent website. I stumbledupon it 😉 I may come back yet again since I book-marked it. Money and freedom is the best way to change, may you be rich and continue to guide other people.

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  237. An intriguing discussion is definitely worth comment. I believe that you should write more on this topic, it might not be a taboo subject but usually folks don’t talk about such subjects. To the next! Kind regards!!

  238. I really love your site.. Very nice colors & theme. Did you develop this website yourself? Please reply back as I’m planning to create my own personal site and want to find out where you got this from or just what the theme is named. Thank you!

  239. I’m amazed, I have to admit. Rarely do I come across a blog that’s both educative and engaging, and let me tell you, you have hit the nail on the head. The issue is something that too few men and women are speaking intelligently about. I am very happy I found this during my search for something concerning this.

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  241. May I simply just say what a relief to find someone who truly understands what they are discussing on the web. You certainly understand how to bring a problem to light and make it important. More and more people should check this out and understand this side of your story. I was surprised that you are not more popular given that you definitely possess the gift.

  242. I’m amazed, I have to admit. Seldom do I come across a blog that’s both educative and amusing, and without a doubt, you’ve hit the nail on the head. The issue is something that not enough men and women are speaking intelligently about. I am very happy I came across this during my hunt for something concerning this.

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